More years. More choices.

The one supplement I might throw away first

A new aging mechanism puts iron on trial, and it matters even if you never bought an iron pill.

Eight longevity compounds failed to extend mouse lifespan

What a rigorous mouse study changed about my supplement choices.

Peptides get the hype. What about amino acids?

GlyNAC, creatine, and protein needs: what small human trials and mouse studies can tell us.

Your Supplement Might Contain Viagra, Lead, or Poison

How supplement oversight, contamination, and testing work, which claims deserve scrutiny, and how to check a product before buying.

Why biological-age tests disagree and what I use them for

How biological-age estimates differ, what common bloodwork can tell us, and why a changed age score does not prove a treatment slows aging.

New evidence on adult brain cells and how I approach brain health

A human hippocampal study adds evidence on adult neurogenesis. I explain its limits and share the habits I use to support brain health.

Is 50% of your lifespan already "decided"?

Why I prescribe Rapamycin - but not to most of my patients

GRAIL's Cancer Test Just Failed Its Big Trial. Here's Why I Still Use It.

The NHS-Galleri trial’s unmet primary endpoint, favorable secondary findings, screening tradeoffs, and the future Medicare coverage conditions.

He started running at 66. His fitness after 80 is exceptional.

An exceptional runner’s fitness after eighty, a lifestyle trial’s aging-marker findings, and the cardio routine I use without universal dose claims.

My Unusual Body Recomp Stack

My January 2026 body-recomposition experiment with food tracking, exercise, and acarbose, with clear limits on drug and lifespan claims.

The Longevity Letter #5: Beyond the Rash: How the Shingles Vaccine Slows Biological Aging

Research on shingles vaccination, immune aging, and dementia risk, with a personal account of post-COVID care.

Gray market peptides: A harm reduction guide

What research-only labels and purity reports can tell you about peptides, where their limits lie, and why clinical oversight matters.

The Longevity Letter #1: Your 2026 Longevity Upgrade: Brain & Mitochondria (Part 2)

Most resolutions fail because great habits can’t fix worn-out biology. Learn how to boost brain, mitochondria, and longevity in 2026 with evidence-backed strategies.

The 3 longevity protocols hitting mainstream in 2026

Three longevity protocols moving from biohacker fringe to mainstream medicine in 2026, and the clinical evidence behind each.

The free shot that might prevent dementia (for some!)

New data just dropped. Here's what it means.

Can you trip your way to a younger biological age? 🍄

Why one feast won't age you (but your daily habits might)

Stem Cells, Skin Longevity, and Why I'm Equally Excited and Skeptical

My November 2025 conference notes on regenerative therapies, skin care, seafood, and Mimio, with the evidence and questions behind each.

Should you throw out your melatonin? Study links to heart failure

New preliminary data on heart failure risk + the tolerance problem nobody talks about. Context matters.

This whale lives 200 years and never gets cancer. Here's why.

The bowhead whale lives 200+ years and virtually never develops cancer. Scientists now understand why, and the implications for human longevity.

What I told 700 longevity health optimizers in Silicon Valley

Tier 1 gets you 80% of the way. Tier 2 gets you to 99%. Most people skip straight to Tier 3. Here's the right order →

This ugly rodent lives 500 human years (and we know why)

Scientists cracked the code on living 10x longer

Why your $100/month NAD+ supplement isn't working

New research reveals the missing piece: mitochondrial structure, not just fuel

The 117-year-old who broke longevity rules

New research: chronic dehydration = 55% higher cortisol. Check your morning urine color...

Insurance companies are panicking about your lifespan

GLP-1s might extend lives by 6.4%. Meanwhile, AI just replaced PhD students and brain pills hit trials.

Apple just said the word “Longevity” out loud

Apple officially entered the longevity space. What this signals for health-tech, wearables, and the future of preventive medicine.

Could tiny doses of Ozempic really work for longevity?

Could microdosing semaglutide (Ozempic) at sub-therapeutic levels provide longevity benefits without the side effects? A physician's analysis of the emerging data.

Simple cooking tricks that slow aging by 50%

Lemon juice & vinegar are longevity game-changers because of this prominent aging process happening inside our bodies every day

The Longevity Letter #13: Your Clone, Your Organs—And Maybe Your 150-Year Lifespan

Discover the controversial "gestation robot" planned for 2026, the new UCLA molecule that wakes up dormant hair follicles.

The Longevity Letter #12: Stanford just found the ultimate death predictor (not what you think)

What blood proteins may reveal about brain aging and disease risk, plus early research on light and sound stimulation for Alzheimer's disease.

The Longevity Letter #11: Peptide Craze and Plastic Brains, and Exposing the Hidden Dangers of ‘Healthy’ Bars

A look at peptide safety, ovarian aging research, microplastics, and the health claims made for ultra-processed foods.

The Longevity Letter #9: Your commute is aging your brain (but cough medicine might save it)

Discover how your daily commute accelerates brain aging, the common $5 cough syrup showing promise for dementia, and the massive FDA reversal on hormone therapy that challenges decades of medical dogm

The Longevity Letter #8: 3 breakthroughs that could reverse aging by 2030

Research on dog longevity, brain cell repair, and GLP-1 medicines, with questions about what those findings could mean for human health.

The Longevity Letter #10: 3 longevity breakthroughs that could add decades to your life

Early research on retinal aging tests, psilocybin, and drug combinations in longevity science.

The Longevity Letter #7: Why your 40-year-old body betrays you at the gym (solved)

Research on CLCF1, exercise and aging, plus a review of the evidence for metformin as a longevity drug.

The Longevity Letter #6: The shift from guesswork to precision medicine for true longevity

From reviving sluggish mitochondria and replacing painful biopsies with nanoneedles to detecting Parkinson’s via earwax, this week's issue unpacks the latest breakthroughs moving us from medical

There's science to why Netflix makes you overeat

The neuroscience of why Netflix binges trigger overeating, and what the research says about breaking the cycle.

Last year's miracle longevity supplement just got destroyed

The everyday drink that adds years to your life, plus more longevity news from June 1-7

What if aging is just dirty blood we can clean?

Plus: Stanford scientist's secret weapon against aging is touching grass (literally) and other wild developments...

CRISPR baby makes history + the AI that beat 262 doctors

Scientists discover NSAIDs may accelerate aging + the nutrition approach that could save your vision.

The Longevity Letter #4: Stanford Expert's Controversial Take: "Skip All 500 Supplements"

You’re seeing the latest in longevity—from AI in clinics to full-body MRIs, metformin, and wearables—but not every new tool lives up to the hype. We dive into what’s truly evidence-backed and how to s

The Longevity Letter #3: Rapamycin passes 48‑week safety test—what it means for your clinic

Rapamycin just cleared a 48-week safety milestone, offering promising insights for clinicians exploring precision longevity protocols. From senolytic breakthroughs to AI-assisted biomarkers, discover

The secret of longevity isn't in new drugs—it's in connecting dots we already have

The most exciting medical breakthroughs might already exist - we just need to connect the dots. Here's how we're doing it with AI systems built in...

Why Now Is the Perfect Moment for Longevity Medicine

Three converging forces are transforming healthcare as we know it. Are you ready to join us?

Beyond cold plunges: the real longevity breakthrough

Beyond cold plunges and biohacking trends, the real longevity breakthrough is far simpler and more evidence-based than you think.

Your Brain Fog Isn't 'All in Your Head' - Here's Why

Brain fog isn't just in your head. The biological mechanisms behind cognitive fog and evidence-based strategies to clear it.

The #1 Problem Longevity Doctors Keep DMing Me About: Data Management

The biggest operational challenge in longevity medicine isn't clinical. It's data management. Here's why doctors keep DMing me about it.

Where is Longevity Health Innovation Going?

Where longevity health innovation is heading: the convergence of AI, precision medicine, and consumer demand for healthspan extension.

Why I Started a Longevity Clinic and How You Can Benefit

Are outdated healthcare practices holding us back? See how embracing change - and longevity healthcare - can lead to better living.

Birth Control Warning: What the New Study Means for You and Your Partner

Hormones feeling out of whack? Here's what every woman (and man!) should know right now.

Perimenopause Revealed: The Health Shift No One Talks About

Hormones feeling out of whack? Here's what every woman (and man!) should know right now.

Can COVID Make You Age Faster? The Science Behind It"

From accelerated aging to fertility concerns, COVID’s hidden effects are becoming clearer. Let’s dive into what this means for longevity.

Breaking Free from Insurance: A $4.5 Trillion Healthcare Revolution

Uncover the key to longevity medicine and why it's not just for the ultra-rich...

Is HRT Making a Comeback? Plus: Essential Hormone Tests & Hair Health Secrets

New perspectives on HRT, must-have hormone tests, and hair health tips...

🔬 New health podcast + birthday week reverse aging news 🔄

The true cost of longevity might surprise you. Plus, exciting new projects...

Whole wheat or white flour? What changes in your bread