Mitochondria, NAD, and Fatigue: Evidence and Caveats

Fatigue and low energy are often marketed as a supplement problem, but mitochondrial health starts with the basics: sleep, movement, nutrition, recovery, and metabolic context. In this episode, Dr. Hillary Lin reviews foundational energy habits and then walks through the evidence and caveats around NAD+ precursors, CoQ10, PQQ, and urolithin A.

Important: this episode discusses supplements and early-stage longevity science. Evidence varies by compound, and many studies are small, short-term, or focused on biomarkers rather than real-world fatigue outcomes. Do not treat this episode as a protocol for treating fatigue, and talk with a qualified clinician before starting supplements, especially if you are pregnant, breastfeeding, managing a medical condition, taking blood thinners, diabetes medications, or receiving cancer treatment.